How non-coding RNAs shape nuclear structure to regulate gene expression

The nucleus is a highly organized arrangement of RNA, DNA, and protein molecules that are compartmentalized within three-dimensional (3D) structures involved in shared functional regulatory processes. Although RNA has long been proposed to play global role organizing nuclear structure, exploring this remained challenge because no existing methods can simultaneously measure DNA contacts 3D structures. To address this, we developed & SPRITE (RD-SPRITE) comprehensively map the spatial organization all RNAs relative DNA.